BDBM50192881 CHEMBL3914602::US10329299, Compound 30::US10675286, Compound 30::US11541059, Compound 30::US9775844, Compound 30

SMILES C[C@H](NC(=O)c1c(N)nn2cccnc12)c1cc2cccc(C#Cc3ccn(C)n3)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=VQWJJVZHAWENFG-UHFFFAOYSA-N

Data  20 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 20 hits for monomerid = 50192881   

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:A PI3-Kinase HTRF assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used speci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 3.00E+3nMAssay Description:PI3 Kinase α, β, γ or δ activity was assayed using the PI3 Kinase HTRF assay kit (catalogue No. 33-016) purchased from Millipore ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:PI3 Kinase α, β, γ or δ activity was assayed using the PI3 Kinase HTRF assay kit (catalogue No. 33-016) purchased from Millipore ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:PI3 Kinase α, β, γ or δ activity was assayed using the PI3 Kinase HTRF assay kit (catalogue No. 33-016) purchased from Millipore ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:PI3 Kinase α, β, γ or δ activity was assayed using the PI3 Kinase HTRF assay kit (catalogue No. 33-016) purchased from Millipore ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 5.00E+3nMAssay Description:A compound's ability in selectively inhibiting PI3K-γ can be assessed using RAW264.7 macrophages. Briefly, serum-starved RAW264.7 cells are ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 4.00E+3nMAssay Description:A compound's ability in selectively inhibiting PI3K-δ can be assessed using RAJI cells, i.e., B lymphocyte cells derived from lymphoma patie...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 3.00E+3nMAssay Description:A PI3-Kinase HTRF assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used speci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:A PI3-Kinase HTRF assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used speci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:A PI3-Kinase HTRF assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used speci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/10/2021
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 9.00E+3nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged PI3K p110delta/p85alpha coexpressed in baculovirus infected Sf9 insect cells using ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed
LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 3.00E+3nMAssay Description:A PI3-Kinase HTRF assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used speci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:A PI3-Kinase HTRF assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used speci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:A PI3-Kinase HTRF assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used speci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:A PI3-Kinase HTRF assay kit (cat No. 33-016) purchased from Millipore Corporation was used to screen compounds provided herein. This assay used speci...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/31/2020
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 3.00E+3nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 2.00E+3nMAssay Description:Class I PI3-Ks can be either purchased (p110α/p85α, p110β/p85α, p110δ/p85α from Upstate, and p110γ from Sigma) or ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/11/2019
Entry Details
Go to US Patent

LigandPNGBDBM50192881(CHEMBL3914602 | US9775844, Compound 30 | US1032929...)
Affinity DataIC50: 100nMAssay Description:Inhibition of human recombinant full length N-terminal His-tagged PI3Kgamma expressed in Sf9 insect cells using diC8PIP2 as substrate incubated for 1...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2018
Entry Details Article
PubMed