BDBM50193020 CHEMBL3907932::US11155556, No. 7

SMILES CN1c2ccc(C)cc2C(=O)N(C)c2cnc(Nc3cccc(c3)S(=O)(=O)Nc3cccc(NC(=O)C=C)c3)nc12

InChI Key InChIKey=OETFNYXAELUUOC-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50193020   

TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193020(CHEMBL3907932 | US11155556, No. 7)
Affinity DataIC50: 130nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193020(CHEMBL3907932 | US11155556, No. 7)
Affinity DataIC50: 330nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193020(CHEMBL3907932 | US11155556, No. 7)
Affinity DataIC50: 190nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193020(CHEMBL3907932 | US11155556, No. 7)
Affinity DataIC50: 39nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetPhosphatidylinositol 3-kinase C2 domain-containing subunit gamma(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50193020(CHEMBL3907932 | US11155556, No. 7)
Affinity DataIC50: 39nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

LigandPNGBDBM50193020(CHEMBL3907932 | US11155556, No. 7)
Affinity DataIC50: 328nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193020(CHEMBL3907932 | US11155556, No. 7)
Affinity DataIC50: 188nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193020(CHEMBL3907932 | US11155556, No. 7)
Affinity DataIC50: 130nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent