BDBM50193031 CHEMBL3959351::US11155556, No. 12

SMILES CN1c2ccc(C)cc2C(=O)N(C)c2cnc(Nc3cccc(c3)S(=O)(=O)N3CCC(O)CC3)nc12

InChI Key InChIKey=GHKMIOAEPALCFS-UHFFFAOYSA-N

Data  14 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 14 hits for monomerid = 50193031   

TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 150nMAssay Description:Inhibition of human Aurora kinase A (E122 to K401 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human PI3Kbeta (P118 to S1070 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 6.5nMAssay Description:Inhibition of human PI3Kgamma (S144 to A1102 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 150nMAssay Description:Inhibition of human Aurora kinase B (D25 to A303 residues) expressed in mammalian expression system by Z'LYTE assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 55nMAssay Description:Inhibition of human PI3Kalpha (R108 to N1068 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 2.10nMAssay Description:Inhibition of human PI3Kdelta (R108 to Q1044 residues) expressed in mammalian expression system incubated for 60 mins by ADAPTA assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
TargetBromodomain-containing protein 4(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 1.08E+4nMAssay Description:Inhibition of BRD4 bromodomain 1 (unknown origin) by Alphascreen assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/1/2018
Entry Details Article
PubMed
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 2nMAssay Description:Inhibition of PI3Kdelta (unknown origin)More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2021
Entry Details Article
PubMed
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 55nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 4.75E+3nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetPhosphatidylinositol 3-kinase C2 domain-containing subunit gamma(Human)
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 2nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 7nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetAurora kinase A(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 151nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent

TargetAurora kinase B(Human)
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50193031(CHEMBL3959351 | US11155556, No. 12)
Affinity DataIC50: 152nMAssay Description:The enzymatic activities against PI3K-α, PI3K-β, PI3K-γ and PI3K-δ were tested in ADAPTA assays. Activity against AURKB and AURKB...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/13/2022
Entry Details
Go to US Patent