BDBM50193662 CHEMBL3911607

SMILES Cc1cc(C)c(CN2CCc3c(Cl)cc(-c4cn[nH]c4)c(Cl)c3C2=O)c(=O)[nH]1

InChI Key InChIKey=MQFPEQKHLBSYOY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50193662   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193662(CHEMBL3911607)
Affinity DataIC50: 51nMAssay Description:Inhibition of wild-type EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex using HeLa cells der...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193662(CHEMBL3911607)
Affinity DataIC50: 1.73E+3nMAssay Description:Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27Me3 levels after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed