BDBM50193712 CHEMBL3919969

SMILES Cc1n[nH]c(C)c1-c1cc(Cl)c2CCN(Cc3c(C)cc(C)[nH]c3=O)C(=O)c2c1Cl

InChI Key InChIKey=MIXSULSYLMZXLD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50193712   

TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193712(CHEMBL3919969)
Affinity DataIC50: 16nMAssay Description:Inhibition of wild-type EZH2 (unknown origin) expressed in baculovirus infected SF9 cells co-expressing SUZ12/EED/RbAp48 complex using HeLa cells der...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed
TargetHistone-lysine N-methyltransferase EZH2(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50193712(CHEMBL3919969)
Affinity DataIC50: 502nMAssay Description:Inhibition of EZH2 in human KARPAS422 cells assessed as reduction in H3K27Me3 levels after 72 hrs by ELISAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/4/2018
Entry Details Article
PubMed