BDBM50195545 CHEMBL3923932

SMILES COc1cc(cc(Br)c1OC)C1CC(=NN1C(C)=O)c1ccc2ccccc2c1

InChI Key InChIKey=QVILVVZPQRESCR-UHFFFAOYSA-N

Data  2 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50195545   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University Bayreuth

Curated by ChEMBL

LigandBDBM50195545(CHEMBL3923932)Copy SMILESCopy InChI

Affinity DataIC50: 8.90E+3nMAssay Description:Inhibition of BCRP in human MCF7/Topo cells assessed as mitoxantrone accumulation preincubated for 10 mins followed by mitoxantrone addition measured...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/9/2018
Entry Details Article
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TargetATP-dependent translocase ABCB1(Human)
University Bayreuth

Curated by ChEMBL

LigandBDBM50195545(CHEMBL3923932)Copy SMILESCopy InChI

Affinity DataIC50: 1.26E+4nMAssay Description:Inhibition of P-gp in human KB-V1/Vbl cells assessed as calcein-AM accumulation preincubated for 15 mins followed by calcein-AM addition measured aft...More data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
7/9/2018
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL