BDBM50195784 CHEMBL3889771

SMILES CCCCCCc1nc(ncc1C(=O)N(CC(C)C)[C@@H]1CNC[C@@H](C1)C(=O)N1CCOCC1)C(C)(C)C

InChI Key InChIKey=MVIGGJLXXAWWJX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50195784   

TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195784(CHEMBL3889771)
Affinity DataIC50: 10nMAssay Description:Inhibition of renin in human plasma by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195784(CHEMBL3889771)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human preprorenin expressed in human 293F cells using angiotensinogen as substrate preincubated for 10 mins followed by sub...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/10/2018
Entry Details Article
PubMed
TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195784(CHEMBL3889771)
Affinity DataIC50: 10nMAssay Description:Inhibition of renin in human plasma by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMed
TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195784(CHEMBL3889771)
Affinity DataIC50: 24nMAssay Description:Inhibition of recombinant human renin using angiotensinogen as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMed
TargetRenin(Human)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50195784(CHEMBL3889771)
Affinity DataIC50: 29nMAssay Description:Inhibition of recombinant human renin using angiotensinogen as substrate pretreated for 10 mins followed by substrate addition measured after 30 mins...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/5/2020
Entry Details Article
PubMed