BDBM50196729 CHEMBL3923840

SMILES CCOc1ccc(CN2CCN(CC2)c2ncc(cn2)C(=O)NO)cc1-c1nc2c(CC)nn(C)c2c(=O)[nH]1

InChI Key InChIKey=AUCLUKFMBLSKNX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50196729   

TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50196729(CHEMBL3923840)
Affinity DataIC50: 7nMAssay Description:Inhibition of full length recombinant human N-terminal GST-tagged PDE5A1 expressed in baculovirus infected Sf9 cells using cGMP as substrate after 30...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50196729(CHEMBL3923840)
Affinity DataIC50: 14nMAssay Description:Inhibition of full length recombinant human C-terminal His/Flag-tagged HDAC1 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC subst...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50196729(CHEMBL3923840)
Affinity DataIC50: 89nMAssay Description:Inhibition of full length recombinant human C-terminal His-tagged HDAC2 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
University of Navarra

Curated by ChEMBL
LigandPNGBDBM50196729(CHEMBL3923840)
Affinity DataIC50: 379nMAssay Description:Inhibition of full length recombinant human N-terminal GST tagged HDAC6 expressed in baculovirus infected Sf9 cells using fluorogenic HDAC substrate ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/12/2018
Entry Details Article
PubMed