BDBM50198497 (S)-6-(4-fluorophenyl)-N-methyl-N-(6-((3-oxopiperazin-1-yl)methyl)-1,2,3,4-tetrahydronaphthalen-2-yl)nicotinamide::CHEMBL216429

SMILES CN([C@H]1CCc2cc(CN3CCNC(=O)C3)ccc2C1)C(=O)c1ccc(nc1)-c1ccc(F)cc1

InChI Key InChIKey=YJAPXTJNXJHOJK-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50198497   

TargetMelanin-concentrating hormone receptor 1(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198497((S)-6-(4-fluorophenyl)-N-methyl-N-(6-((3-oxopipera...)
Affinity DataKi:  3.47E+3nMAssay Description:Functional antagonism of MCH-R1 expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMelanin-concentrating hormone receptor 1(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198497((S)-6-(4-fluorophenyl)-N-methyl-N-(6-((3-oxopipera...)
Affinity DataIC50: 3.50E+3nMAssay Description:Antagonist activity at MCHR1 (unknown origin) expressed in CHO cells co-expressing aequorin incubated for 10 mins by luminescence assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/25/2021
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Procter & Gamble Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50198497((S)-6-(4-fluorophenyl)-N-methyl-N-(6-((3-oxopipera...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of binding to serotonin receptor 5HT2CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed