BDBM50199602 (S)-4-(4-methoxyphenyl)-2-methyl-7-(3-((S)-3-methylmorpholino)propoxy)-1,2,3,4-tetrahydroisoquinoline::CHEMBL395609

SMILES COc1ccc(cc1)[C@@H]1CN(C)Cc2cc(OCCCN3CCOC[C@@H]3C)ccc12

InChI Key InChIKey=DIMAAAZZSSXDEH-UHFFFAOYSA-N

Data  5 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50199602   

TargetSodium-dependent serotonin transporter(Rat)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50199602((S)-4-(4-methoxyphenyl)-2-methyl-7-(3-((S)-3-methy...)
Affinity DataKi:  5nMAssay Description:Binding affinity at rat SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetHistamine H3 receptor(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50199602((S)-4-(4-methoxyphenyl)-2-methyl-7-(3-((S)-3-methy...)
Affinity DataKi:  5.60nMAssay Description:Binding affinity at human histamine H3 receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50199602((S)-4-(4-methoxyphenyl)-2-methyl-7-(3-((S)-3-methy...)
Affinity DataKi:  13nMAssay Description:Binding affinity at human SERTMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50199602((S)-4-(4-methoxyphenyl)-2-methyl-7-(3-((S)-3-methy...)
Affinity DataKi:  102nMAssay Description:Inhibition of [3H]WIN-uptake in human DAT expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent noradrenaline transporter(Human)
Johnson & Johnson Pharmaceutical Research and Development

Curated by ChEMBL
LigandPNGBDBM50199602((S)-4-(4-methoxyphenyl)-2-methyl-7-(3-((S)-3-methy...)
Affinity DataKi:  121nMAssay Description:Inhibition of [3H]nisoxetine uptake in human NET expressed in MDCK cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed