BDBM50199659 CHEMBL392788::US8481733, Comparator 1::cis-3-(3-(aminomethyl)cyclobutyl)-1-(3-(benzyloxy)phenyl)imidazo[1,5-a]pyrazin-8-amine

SMILES NC[C@H]1C[C@H](C1)c1nc(-c2cccc(OCc3ccccc3)c2)c2c(N)nccn12

InChI Key InChIKey=ZKDZHSAMEVMGFN-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50199659   

TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199659(US8481733, Comparator 1 | CHEMBL392788 | cis-3-(3-...)
Affinity DataIC50: 60nMAssay Description:Inhibition of human recombinant GST-IGF1R activityMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetInsulin-like growth factor 1 receptor(Human)
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50199659(US8481733, Comparator 1 | CHEMBL392788 | cis-3-(3-...)
Affinity DataIC50: 690nMAssay Description:Inhibition of IGF1-stimulated phosphorylation of human recombinant IGF1R expressed in NIH3T3 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetActivated CDC42 kinase 1(Human)
Osi Pharmaceuticals

US Patent
LigandPNGBDBM50199659(US8481733, Comparator 1 | CHEMBL392788 | cis-3-(3-...)
Affinity DataIC50: 1.02E+4nMAssay Description:Compounds of the invention were tested for ACK1 inhibition activity. 1 uL compounds prepared at 15× in 4 mM DMSO were combined with 9 uL ATP so...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/19/2013
Entry Details
US Patent