BDBM50200434 CHEMBL3986361::US9763922, Example 196

SMILES CC(=O)N1CCc2c(C1)c(Nc1cccc(C)c1)nn2Cc1cccnc1

InChI Key InChIKey=IMLLQTJDJJVPOT-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50200434   

TargetBromodomain-containing protein 4(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50200434(CHEMBL3986361 | US9763922, Example 196)
Affinity DataIC50: 5.60E+3nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged BRD4 bromodomain-1 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
LigandPNGBDBM50200434(CHEMBL3986361 | US9763922, Example 196)
Affinity DataIC50: 140nMAssay Description:Displacement of biotinylated ligand from recombinant His-tagged CBP/EP300 (unknown origin) measured after 10 mins by TR-FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
7/26/2018
Entry Details Article
PubMed
TargetCREB-binding protein(Human)
Genentech

US Patent
LigandPNGBDBM50200434(CHEMBL3986361 | US9763922, Example 196)
Affinity DataIC50: 290nMAssay Description:His/Flag epitope tagged CBP was cloned, expressed, and purified to homogeneity. CBP binding and inhibition was assessed by monitoring the engagement ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
7/30/2019
Entry Details
Go to US Patent