BDBM50201564 CHEMBL3890777

SMILES c1cc(nc(c1)Br)NC(=O)[C@H]2N(CCS2)C(=O)Cn3c4c(cccn4)c(n3)C(=O)N

InChI Key InChIKey=AOOWOKALXAVACG-UHFFFAOYSA-N

Data  3 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50201564   

TargetComplement factor D(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50201564(CHEMBL3890777)
Affinity DataIC50: 19nMAssay Description:Inhibition of recombinant human C-terminal 6His-tagged complement factor D (26 to 253 residues) expressed in Sf9 insect cells preincubated for 1 hr f...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50201564(CHEMBL3890777)
Affinity DataKd:  19nMAssay Description:Binding affinity to recombinant human C-terminal 6His-tagged/biotinylated complement factor D (26 to 253 residues) expressed in Sf9 insect cells by b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50201564(CHEMBL3890777)
Affinity DataIC50: 27nMAssay Description:Competitive inhibition of human complement factor D preincubated for 1 hr followed by addition of Z-Lys-thiobenzyl ester as substrate measured over 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50201564(CHEMBL3890777)
Affinity DataIC50: 205nMAssay Description:Inhibition of human serum factor D-mediated complement activation in rabbit erythrocytes assessed as reduction in rabbit erythrocyte hemolysis preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)