BDBM50201569 CHEMBL3924715

SMILES c1ccc2c(c1)cnn2CC(=O)N3CCS[C@H]3C(=O)Nc4cccc(n4)Br

InChI Key InChIKey=JSZBVXMPHMCOIC-UHFFFAOYSA-N

Data  2 IC50  1 Kd

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50201569   

TargetComplement factor D(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50201569(CHEMBL3924715)
Affinity DataKd:  2.21E+3nMAssay Description:Binding affinity to recombinant human C-terminal 6His-tagged/biotinylated complement factor D (26 to 253 residues) expressed in Sf9 insect cells by b...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50201569(CHEMBL3924715)
Affinity DataIC50: 77nMAssay Description:Inhibition of human serum factor D-mediated complement activation in rabbit erythrocytes assessed as reduction in rabbit erythrocyte hemolysis preinc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetComplement factor D(Human)
University of Michigan

Curated by ChEMBL
LigandPNGBDBM50201569(CHEMBL3924715)
Affinity DataIC50: 2.18E+3nMAssay Description:Competitive inhibition of human complement factor D preincubated for 1 hr followed by addition of Z-Lys-thiobenzyl ester as substrate measured over 5...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/1/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)