BDBM50202242 CHEMBL3967096

SMILES CCCOc1ccc2[nH]cc(CCNC(=O)c3cc(=O)c4c(OCc5ccc(Br)cc5)cccc4o3)c2c1

InChI Key InChIKey=XELOPBHZLGUENJ-UHFFFAOYSA-N

Data  2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50202242   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lyon 1

Curated by ChEMBL

LigandBDBM50202242(CHEMBL3967096)Copy SMILESCopy InChI

Affinity DataEC50:  280nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as reduction in mitoxantrone efflux after 30 mins by flow cytometric analysisMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
8/3/2018
Entry Details Article
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TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
University of Lyon 1

Curated by ChEMBL

LigandBDBM50202242(CHEMBL3967096)Copy SMILESCopy InChI

Affinity DataEC50:  2.80E+8nMAssay Description:Inhibition of ABCG2 (unknown origin) expressed in HEK293 cells assessed as increase in mitoxantrone accumulation incubated for 30 mins by flow cytome...More data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
2/25/2021
Entry Details Article
Copy BDB DOIPubMed
Copy reaction URL