BDBM50203235 CHEMBL3963161

SMILES Nc1ncc(Cn2cc(-c3cccc(c3)C(F)(F)F)c3ccccc23)c(N)n1

InChI Key InChIKey=TZZFGNIDHKLBES-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50203235   

TargetDihydrofolate reductase(Human)
Turing Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50203235(CHEMBL3963161)
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human DHFR expressed in Escherichia coli preincubated for 15 mins followed by addition of DHF as substrate and NADPH measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2018
Entry Details Article
PubMed
TargetBifunctional dihydrofolate reductase-thymidylate synthase(Toxoplasma gondii)
Turing Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50203235(CHEMBL3963161)
Affinity DataIC50: 980nMAssay Description:Inhibition of Toxoplasma gondii TS-DHFR expressed in Escherichia coli BL21 preincubated for 15 mins followed by addition of DHF as substrate and NADP...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/6/2018
Entry Details Article
PubMed