BDBM50203426 CHEMBL3962413

SMILES CC[C@@H]1C[C@@]([C@H](c2c1c(c(c(c2)F)F)O)Nc3cccc4c3C=CC(=O)N4)(C(F)(F)F)O

InChI Key InChIKey=VZPLUSXTJULLCS-UHFFFAOYSA-N

Data  8 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50203426   

TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203426(CHEMBL3962413)
Affinity DataIC50: 1.20nMAssay Description:Agonist activity at glucocorticoid receptor in human ChaGoK1 cells assessed as inhibition of AP1-mediated transcriptional activity by measuring reduc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/8/2018
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetAndrogen receptor(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50203426(CHEMBL3962413)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to recombinant human androgen receptor expressed in baculovirus infected sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2020
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50203426(CHEMBL3962413)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to recombinant human mineralocorticoid receptor expressed in baculovirus infected sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2020
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Bayer Pharma

Curated by ChEMBL
LigandPNGBDBM50203426(CHEMBL3962413)
Affinity DataIC50: 1.00E+3nMAssay Description:Binding affinity to recombinant human progesterone receptor expressed in baculovirus infected sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2020
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203426(CHEMBL3962413)
Affinity DataIC50: 6.30nMAssay Description:Transrepression activity at glucocorticoid receptor in human THP1 cells assessed as receptor-mediated anti-inflammatory activity by measuring inhibit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203426(CHEMBL3962413)
Affinity DataIC50: 10nMAssay Description:Transactivation activity at glucocorticoid receptor in human HeLa cells assessed as induction of MMTV promoter activity by luciferase reporter gene a...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203426(CHEMBL3962413)
Affinity DataIC50: 6.30nMAssay Description:Transrepression activity at glucocorticoid receptorin human HeLa cells assessed as inhibition of TPA-induced collagenase promoter activity by lucifer...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)
TargetGlucocorticoid receptor(Human)
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50203426(CHEMBL3962413)
Affinity DataIC50: 63nMAssay Description:Binding affinity to recombinant human glucocorticoid receptor expressed in baculovirus infected sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/8/2020
Entry Details Article
PubMedPDB3D3D Structure (crystal)