BDBM50203938 (S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-4-yl)pyrrolidin-3-amine::CHEMBL245880

SMILES Clc1cccc(CN([C@H]2CCNC2)C2CCOCC2)c1Cl

InChI Key InChIKey=PIMIZGGCAMLEJJ-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50203938   

TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of [3H]5-HT from human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [3H]NA from human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 89nMAssay Description:Inhibition of [3H]DA from human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 5nMAssay Description:Inhibition of [3H]NA uptake at human NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent serotonin transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 10nMAssay Description:Inhibition of [3H]5HT uptake at human SERT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetSodium-dependent dopamine transporter(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 89nMAssay Description:Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50203938((S)-N-(2,3-dichlorobenzyl)-N-(tetrahydro-2H-pyran-...)
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed