BDBM50204832 4-(2-(5-bromo-2-fluorophenyl)pteridin-4-ylamino)-N-(3-(2-oxopyrrolidin-1-yl)propyl)nicotinamide::CHEMBL234655

SMILES Fc1ccc(Br)cc1-c1nc(Nc2ccncc2C(=O)NCCCN2CCCC2=O)c2nccnc2n1

InChI Key InChIKey=GZOYOEIHAGHGFM-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50204832   

LigandPNGBDBM50204832(4-(2-(5-bromo-2-fluorophenyl)pteridin-4-ylamino)-N...)
Affinity DataIC50: 123nMAssay Description:Inhibition of human VEGFR3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50204832(4-(2-(5-bromo-2-fluorophenyl)pteridin-4-ylamino)-N...)
Affinity DataIC50: 47nMAssay Description:Inhibition of human VEGFR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 10(Human)
Tibotec

Curated by ChEMBL
LigandPNGBDBM50204832(4-(2-(5-bromo-2-fluorophenyl)pteridin-4-ylamino)-N...)
Affinity DataIC50: 59nMAssay Description:Inhibition of human JNK3More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 8(Human)
Tibotec

Curated by ChEMBL
LigandPNGBDBM50204832(4-(2-(5-bromo-2-fluorophenyl)pteridin-4-ylamino)-N...)
Affinity DataIC50: 1.05E+4nMAssay Description:Inhibition of JNK1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetTGF-beta receptor type-1(Human)
Tibotec

Curated by ChEMBL
LigandPNGBDBM50204832(4-(2-(5-bromo-2-fluorophenyl)pteridin-4-ylamino)-N...)
Affinity DataIC50: 3.20nMAssay Description:Inhibition of TGFBR1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMitogen-activated protein kinase 9(Human)
Tibotec

Curated by ChEMBL
LigandPNGBDBM50204832(4-(2-(5-bromo-2-fluorophenyl)pteridin-4-ylamino)-N...)
Affinity DataIC50: 37nMAssay Description:Inhibition of human JNK2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50204832(4-(2-(5-bromo-2-fluorophenyl)pteridin-4-ylamino)-N...)
Affinity DataIC50: 140nMAssay Description:Inhibition of human VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed