BDBM50205258 CHEMBL3893822

SMILES Cc1ccc(Oc2ccc(Nc3ncnc4ccc(cc34)-c3cn(CCCCCCC(=O)NO)nn3)cc2C)cn1

InChI Key InChIKey=RZBKGDSTLKCOCW-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50205258   

TargetHistone deacetylase 1(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205258(CHEMBL3893822)
Affinity DataIC50: 5.20nMAssay Description:Inhibition of HDAC1 (unknown origin) using acetylated peptide substrate preincubated for 15 mins followed by substrate addition measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2018
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205258(CHEMBL3893822)
Affinity DataIC50: 10nMAssay Description:Inhibition of wild-type EGFR (unknown origin) assessed as remaining ATP level measured after 15 mins by luminescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2018
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205258(CHEMBL3893822)
Affinity DataIC50: 14nMAssay Description:Inhibition of HDAC6 (unknown origin) using acetylated peptide substrate preincubated for 15 mins followed by substrate addition measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2018
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205258(CHEMBL3893822)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of HER2 (unknown origin) assessed as remaining ATP level measured after 15 mins by luminescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2018
Entry Details Article
PubMed