BDBM50205265 CHEMBL3957055

SMILES ONC(=O)CCCCCCn1cc(nn1)-c1ccc2ncnc(Nc3ccc(F)c(Cl)c3)c2c1

InChI Key InChIKey=UIXUAKVMQUZXGY-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50205265   

TargetEpidermal growth factor receptor(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205265(CHEMBL3957055)
Affinity DataIC50: 0.690nMAssay Description:Inhibition of wild-type EGFR (unknown origin) assessed as remaining ATP level measured after 15 mins by luminescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2018
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205265(CHEMBL3957055)
Affinity DataIC50: 2.60nMAssay Description:Inhibition of HDAC1 (unknown origin) using acetylated peptide substrate preincubated for 15 mins followed by substrate addition measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2018
Entry Details Article
PubMed
TargetHistone deacetylase 6(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205265(CHEMBL3957055)
Affinity DataIC50: 8.40nMAssay Description:Inhibition of HDAC6 (unknown origin) using acetylated peptide substrate preincubated for 15 mins followed by substrate addition measured after 60 min...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2018
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Tsinghua University

Curated by ChEMBL
LigandPNGBDBM50205265(CHEMBL3957055)
Affinity DataIC50: 177nMAssay Description:Inhibition of HER2 (unknown origin) assessed as remaining ATP level measured after 15 mins by luminescence analysisMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/18/2018
Entry Details Article
PubMed