BDBM50205855 CHEMBL3975050

SMILES Cc1ccc2nc(Cn3nc(cc3Cl)C(F)(F)F)cc(=O)n2c1C1CC1

InChI Key InChIKey=GEIOXZFFDIRFRZ-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50205855   

TargetGlutamate receptor 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50205855(CHEMBL3975050)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of human GluA2 receptor flip isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50205855(CHEMBL3975050)
Affinity DataEC50:  1.30E+3nMAssay Description:Positive allosteric modulation of human GluA2 receptor flip isoform assessed as increase in glutamate-induced calcium flux measured at time interval ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, NMDA 1/2A(Human)
Genentech

Curated by ChEMBL
LigandPNGBDBM50205855(CHEMBL3975050)
Affinity DataEC50:  280nMAssay Description:Positive allosteric modulation of GluN1/GluN2A receptor (unknown origin) expressed in CHO cells assessed as increase in glutamate-induced calcium flu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2018
Entry Details Article
PubMed