BDBM50205866 (R)-9-chloro-8-methoxy-1,3,4,10b-tetrahydropyrazino[2,1-a]-isoindol-6(2H)-one::CHEMBL222466

SMILES COc1cc2C(=O)N3CCNC[C@H]3c2cc1Cl

InChI Key InChIKey=NBIPHDGFUDLWID-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50205866   

Target5-hydroxytryptamine receptor 2C(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205866((R)-9-chloro-8-methoxy-1,3,4,10b-tetrahydropyrazin...)
Affinity DataEC50:  246nMAssay Description:Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205866((R)-9-chloro-8-methoxy-1,3,4,10b-tetrahydropyrazin...)
Affinity DataEC50: >1.00E+3nMAssay Description:Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205866((R)-9-chloro-8-methoxy-1,3,4,10b-tetrahydropyrazin...)
Affinity DataEC50: >1.00E+3nMAssay Description:Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205866((R)-9-chloro-8-methoxy-1,3,4,10b-tetrahydropyrazin...)
Affinity DataKi:  471nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205866((R)-9-chloro-8-methoxy-1,3,4,10b-tetrahydropyrazin...)
Affinity DataKi:  1.78E+3nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205866((R)-9-chloro-8-methoxy-1,3,4,10b-tetrahydropyrazin...)
Affinity DataKi:  2.33E+3nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed