BDBM50205887 (4R,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one::CHEMBL376676

SMILES C[C@H]1CNC[C@@H]2N1C(=O)c1c2cccc1C(F)(F)F

InChI Key InChIKey=MNIPSARJNABKIZ-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50205887   

Target5-hydroxytryptamine receptor 2A(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205887((4R,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluor...)
Affinity DataEC50:  370nMAssay Description:Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205887((4R,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluor...)
Affinity DataEC50:  100nMAssay Description:Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205887((4R,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluor...)
Affinity DataEC50:  82nMAssay Description:Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205887((4R,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluor...)
Affinity DataKi:  74nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205887((4R,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluor...)
Affinity DataKi:  116nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205887((4R,10bR)-4-methyl-1,3,4,10b-tetrahydro-7-trifluor...)
Affinity DataKi:  360nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed