BDBM50205888 (R)-9-(1-methylcyclopropyl)-1,3,4,10b-tetrahydro-7-trifluoromethylpyrazino[2,1-a]isoindol-6(2H)-one::CHEMBL220833

SMILES CC1(CC1)c1cc2[C@@H]3CNCCN3C(=O)c2c(c1)C(F)(F)F

InChI Key InChIKey=WJKVURGGNRPOQA-UHFFFAOYSA-N

Data  3 KI  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50205888   

Target5-hydroxytryptamine receptor 2B(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205888((R)-9-(1-methylcyclopropyl)-1,3,4,10b-tetrahydro-7...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human 5HT2B expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205888((R)-9-(1-methylcyclopropyl)-1,3,4,10b-tetrahydro-7...)
Affinity DataEC50: >1.00E+4nMAssay Description:Activity at human 5HT2A expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205888((R)-9-(1-methylcyclopropyl)-1,3,4,10b-tetrahydro-7...)
Affinity DataEC50:  54nMAssay Description:Activity at human 5HT2C expressed in HEK293E cells assessed as elevation of intracellular calcium by 384-FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2B(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205888((R)-9-(1-methylcyclopropyl)-1,3,4,10b-tetrahydro-7...)
Affinity DataKi:  29nMAssay Description:Displacement of [3H]LSD from human recombinant 5HT2B expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205888((R)-9-(1-methylcyclopropyl)-1,3,4,10b-tetrahydro-7...)
Affinity DataKi:  34nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2C expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
Pharmaceutical Research Institute

Curated by ChEMBL
LigandPNGBDBM50205888((R)-9-(1-methylcyclopropyl)-1,3,4,10b-tetrahydro-7...)
Affinity DataKi:  2.31E+3nMAssay Description:Displacement of [125I]DOI from human recombinant 5HT2A expressed in HEK293E cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed