BDBM50207593 (S)-1-(2-AMINO-2-CARBOXYETHYL)-3(2-CARBOXYTHIOPHENE-3-YL-METHYL)-5-METHYLPYRIMIDINE-2,4-DIONE::(S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophene-3-ylmethyl)-5-methylpyrimidine-2,4-dione::CHEMBL373428

SMILES Cc1cn(C[C@H](N)C(O)=O)c(=O)n(Cc2ccsc2C(O)=O)c1=O

InChI Key InChIKey=ZTAZUCRXCRXNSU-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50207593   

TargetGlutamate receptor ionotropic, kainate 1(Rat)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207593((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...)
Affinity DataKd:  18nMAssay Description:Activity at native GLUK5 kainate receptor assessed as antagonism of kainite-induced depolarization of neonatal anaesthetised rat dorsal root fibresMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetGlutamate receptor 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207593((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human recombinant GLUA2-AMPA receptor expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 2(Human)
University Walk

Curated by ChEMBL
LigandPNGBDBM50207593((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...)
Affinity DataIC50: 1.00E+5nMAssay Description:Antagonist activity at human recombinant GLUK6 expressed in HEK293 cells assessed as inhibition of glutamate-stimulated calcium influx by FLIPR assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/9/2012
Entry Details Article
PubMed
TargetGlutamate receptor ionotropic, kainate 3(Rat)
University of Copenhagen

Curated by ChEMBL
LigandPNGBDBM50207593((S)-1-(2-amino-2-carboxyethyl)-3-(2-carboxythiophe...)
Affinity DataKi:  23nMAssay Description:Displacement of [3H]SYM2081 from rat GluK3 expressed in Sf9 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
3/23/2012
Entry Details Article
PubMed