BDBM50207848 CHEMBL246152::N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-yl)pyridin-2-yloxy)phenyl)-3-(trifluoromethoxy)benzamide

SMILES CNc1ncnc(n1)-c1cccnc1Oc1cc(NC(=O)c2cccc(OC(F)(F)F)c2)ccc1C

InChI Key InChIKey=CLLIAZGFVKRLRZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50207848   

LigandPNGBDBM50207848(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 442nMAssay Description:Inhibition of KDR after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207848(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 8nMAssay Description:Inhibition of Tie2 after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAngiopoietin-1 receptor(Human)
Amgen

Curated by ChEMBL
LigandPNGBDBM50207848(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 15nMAssay Description:Inhibition of Tie2 autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
LigandPNGBDBM50207848(N-(4-methyl-3-(3-(4-(methylamino)-1,3,5-triazin-2-...)
Affinity DataIC50: 540nMAssay Description:Inhibition of KDR autophosphorylation in EA.hy926 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed