BDBM50208596 CHEMBL3884587

SMILES COc1ccc(cc1OC)-n1nnc(n1)-c1ccccc1NC(=O)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=RNQGKQSSCCGNPY-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50208596   

TargetBroad substrate specificity ATP-binding cassette transporter ABCG2(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50208596(CHEMBL3884587)
Affinity DataIC50: 330nMAssay Description:Inhibition of recombinant human GFP-fused ABCG2 expressed in MDCK2 cells assessed as reduction in Hoechst 33342 efflux preincubated for 30 mins follo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2018
Entry Details Article
PubMed
TargetATP-dependent translocase ABCB1(Human)
Rheinische Friedrich-Wilhelms-Universit£T Bonn

Curated by ChEMBL
LigandPNGBDBM50208596(CHEMBL3884587)
Affinity DataIC50: 1.02E+4nMAssay Description:Inhibition of ABCB1 in human A2780/ADR cells assessed as reduction in calcien-AM efflux preincubated for 30 mins followed by calcien-AM addition meas...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/2/2018
Entry Details Article
PubMed