BDBM50209097 CHEMBL3885369

SMILES COc1ccc(cc1)S(=O)(=O)N(CCCCCNC(=O)CCCCC(=O)NCCNC(=O)CCN(CCNC(=O)OC(C)(C)C)CCC(=O)NCCNC(=O)CCCCC(=O)NCCCCCN([C@H](CO)C(=O)NO)S(=O)(=O)c1ccc(OC)cc1)[C@H](CO)C(=O)NO

InChI Key InChIKey=YEVVFVQVGXPEQO-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50209097   

Target72 kDa type IV collagenase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50209097(CHEMBL3885369)
Affinity DataKi:  16nMAssay Description:Inhibition of MMP-2 (unknown origin) assessed as inhibition of hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetMatrix metalloproteinase-9(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50209097(CHEMBL3885369)
Affinity DataKi:  18nMAssay Description:Inhibition of human recombinant MMP-9 catalytic domain (112 to 445 residues) expressed in Escherichia coli assessed as inhibition of hydrolysis of Mc...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetMacrophage metalloelastase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50209097(CHEMBL3885369)
Affinity DataKi:  23nMAssay Description:Inhibition of MMP-12 catalytic domain (unknown origin) assessed as inhibition of hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by fluor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetCollagenase 3(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50209097(CHEMBL3885369)
Affinity DataKi:  58nMAssay Description:Inhibition of MMP-13 (unknown origin) assessed as inhibition of hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetInterstitial collagenase(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50209097(CHEMBL3885369)
Affinity DataKi:  143nMAssay Description:Inhibition of MMP-1 (unknown origin) assessed as inhibition of hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed
TargetMatrilysin(Human)
University of Florence

Curated by ChEMBL
LigandPNGBDBM50209097(CHEMBL3885369)
Affinity DataKi:  3.76E+3nMAssay Description:Inhibition of MMP-7 (unknown origin) assessed as inhibition of hydrolysis of Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate by fluorimetric assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/4/2018
Entry Details Article
PubMed