BDBM50210074 CHEMBL3883423

SMILES Cc1nc(N)cc2OCCC\C=C\CCOc3cc(Cn4cccn4)ccc3Cn3cc(cn3)C(=O)NCc12

InChI Key InChIKey=OSLSJEGJCLYVFN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50210074   

TargetPlasma kallikrein(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210074(CHEMBL3883423)
Affinity DataIC50: 153nMAssay Description:Inhibition of human plasma kallikrein using D-Pro-Phe-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetPlasminogen(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210074(CHEMBL3883423)
Affinity DataIC50: 9.97E+3nMAssay Description:Inhibition of Lys-plasmin (unknown origin) using Tosyl-Gly-Pro-Lys-4-nitranilide as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210074(CHEMBL3883423)
Affinity DataIC50: 1.27E+4nMAssay Description:Inhibition of factor 11a (unknown origin) using S-2366 as substrate incubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210074(CHEMBL3883423)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of tPA (unknown origin) using Methylsulfonyl-D-Phe-Gly-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetCoagulation factor XII(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210074(CHEMBL3883423)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of factor 12a (unknown origin) using D-Pro-Phe-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetProthrombin(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210074(CHEMBL3883423)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of alpha-thrombin (unknown origin) using D-Phe-Pip-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed
TargetCoagulation factor X(Human)
Global Blood Therapeutics

Curated by ChEMBL
LigandPNGBDBM50210074(CHEMBL3883423)
Affinity DataIC50: 2.00E+5nMAssay Description:Inhibition of factor 10a (unknown origin) using N-Z-D-Arg-Gly-Arg-pNA as substrate preincubated for 30 mins followed by substrate additionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/7/2018
Entry Details Article
PubMed