BDBM50214918 5-[1-biphenyl-2-yl-meth-(Z)-ylidene]-10-methoxy-2,2,4-trimethyl-2,4a,5,12a-tetrahydro-1H-6-oxa-1-aza-chrysen-9-ol::CHEMBL231757

SMILES COc1c(O)ccc2O\C(=C/c3ccccc3-c3ccccc3)C3=C(C=CC4NC(C)(C)C=C(C)C34)c12

InChI Key InChIKey=PHIKTZJVOVUJJS-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50214918   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214918(5-[1-biphenyl-2-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataIC50: 4.40nMAssay Description:Activity at GR assessed as repression of TNFalpha and IL 1-beta induced E-selectin responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214918(5-[1-biphenyl-2-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataEC50:  4.5nMAssay Description:Agonist activity at GR by GRE activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214918(5-[1-biphenyl-2-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataIC50: 3.60nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214918(5-[1-biphenyl-2-yl-meth-(Z)-ylidene]-10-methoxy-2,...)
Affinity DataKi:  6.70nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed