BDBM50214922 (Z)-5-(3-hydroxybenzylidene)-10-methoxy-2,2,4-trimethyl-2,4a,5,12a-tetrahydro-1H-chromeno[3,4-f]quinolin-9-ol::CHEMBL393946

SMILES COc1c(O)ccc2O\C(=C/c3cccc(O)c3)C3=C(C=CC4NC(C)(C)C=C(C)C34)c12

InChI Key InChIKey=ATJGOPJRRWGHHL-UHFFFAOYSA-N

Data  4 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50214922   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214922((Z)-5-(3-hydroxybenzylidene)-10-methoxy-2,2,4-trim...)
Affinity DataIC50: 1.10nMAssay Description:Activity at GR assessed as repression of TNFalpha and IL 1-beta induced E-selectin responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214922((Z)-5-(3-hydroxybenzylidene)-10-methoxy-2,2,4-trim...)
Affinity DataEC50:  1.5nMAssay Description:Agonist activity at GR by GRE activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214922((Z)-5-(3-hydroxybenzylidene)-10-methoxy-2,2,4-trim...)
Affinity DataIC50: 4.70nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214922((Z)-5-(3-hydroxybenzylidene)-10-methoxy-2,2,4-trim...)
Affinity DataKi:  1.40nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMineralocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214922((Z)-5-(3-hydroxybenzylidene)-10-methoxy-2,2,4-trim...)
Affinity DataKi:  290nMAssay Description:Binding affinity at MRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProgesterone receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214922((Z)-5-(3-hydroxybenzylidene)-10-methoxy-2,2,4-trim...)
Affinity DataKi:  750nMAssay Description:Binding affinity at PRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAndrogen receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214922((Z)-5-(3-hydroxybenzylidene)-10-methoxy-2,2,4-trim...)
Affinity DataKi:  910nMAssay Description:Binding affinity at ARMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed