BDBM50214939 (Z)-5-(2-chlorobenzylidene)-10-methoxy-2,2,4-trimethyl-2,4a,5,12a-tetrahydro-1H-chromeno[3,4-f]quinolin-9-ol::CHEMBL231965

SMILES COc1c(O)ccc2O\C(=C/c3ccccc3Cl)C3=C(C=CC4NC(C)(C)C=C(C)C34)c12

InChI Key InChIKey=LMUPWOQUYNPYMY-UHFFFAOYSA-N

Data  1 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50214939   

TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214939((Z)-5-(2-chlorobenzylidene)-10-methoxy-2,2,4-trime...)
Affinity DataIC50: 18nMAssay Description:Activity at GR assessed as repression of TNFalpha and IL 1-beta induced E-selectin responseMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214939((Z)-5-(2-chlorobenzylidene)-10-methoxy-2,2,4-trime...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at GR by GRE activation assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214939((Z)-5-(2-chlorobenzylidene)-10-methoxy-2,2,4-trime...)
Affinity DataIC50: 24nMAssay Description:Antagonist activity at GR assessed as inhibition of dexamethasone-induced GRE activationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetGlucocorticoid receptor(Human)
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50214939((Z)-5-(2-chlorobenzylidene)-10-methoxy-2,2,4-trime...)
Affinity DataKi:  15nMAssay Description:Displacement of radiolabeled Dexamethasone from glucocorticoid receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed