BDBM50215770 1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carbamoyl)thiazol-4-ylamino)methyl)pyridin-2-yl)-3-ethylurea::CHEMBL247798

SMILES CCNC(=O)Nc1ccc(CNc2ncsc2C(=O)Nc2ccc3OC(F)(F)Oc3c2)cn1

InChI Key InChIKey=BPGIPYJOESFNQI-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50215770   

TargetVascular endothelial growth factor receptor 2(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215770(1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50: 7nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215770(1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50: 122nMAssay Description:Inhibition of b-RafMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase B-raf(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215770(1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50: 824nMAssay Description:Inhibition of P-ERKMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMast/stem cell growth factor receptor Kit(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215770(1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50: 4nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetRAC-alpha serine/threonine-protein kinase(Human)
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215770(1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50: 81nMAssay Description:Inhibition of pAktMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed