BDBM50216171 CHEMBL393545::pyrrolo[3',4':5,6]indolizino[8,7-b]indole-1,3-(2H,8H)-dione

SMILES O=C1NC(=O)c2c1c1c3ccccc3[nH]c1c1cccn21

InChI Key InChIKey=FDOURPSVRVOTSM-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50216171   

TargetSerine/threonine-protein kinase Chk1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50216171(pyrrolo[3',4':5,6]indolizino[8,7-b]indole-1,3-(2H,...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human Chk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetSerine/threonine-protein kinase Chk1(Human)
Université

Curated by ChEMBL
LigandPNGBDBM50216171(pyrrolo[3',4':5,6]indolizino[8,7-b]indole-1,3-(2H,...)
Affinity DataIC50: 24nMAssay Description:Inhibition of human Chk1More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetCyclin-dependent kinase 5 activator 1(Human)
Paul Sabatier University

Curated by ChEMBL
LigandPNGBDBM50216171(pyrrolo[3',4':5,6]indolizino[8,7-b]indole-1,3-(2H,...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human recombinant CDK5/p25More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDual specificity protein kinase CLK1(Mouse)
Paul Sabatier University

Curated by ChEMBL
LigandPNGBDBM50216171(pyrrolo[3',4':5,6]indolizino[8,7-b]indole-1,3-(2H,...)
Affinity DataIC50: 520nMAssay Description:Inhibition of GST-fused mouse recombinant CLK1 expressed in Escherichia coli using RS peptide as substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Rat)
Paul Sabatier University

Curated by ChEMBL
LigandPNGBDBM50216171(pyrrolo[3',4':5,6]indolizino[8,7-b]indole-1,3-(2H,...)
Affinity DataIC50: 1.30E+3nMAssay Description:Inhibition of GST-fused rat recombinant DYRK1A expressed in Escherichia coli using Woodtide as substrate and [gamma-33P] after 30 mins by scintillati...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/7/2013
Entry Details Article
PubMed