BDBM50219112 CHEMBL231156::N-(2-(4-(2,3-dichlorophenyl)piperazin-1-ylmethyl)-trans-cyclopropylmethyl)-4-pyridin-2-ylbenzamide

SMILES Clc1cccc(N2CCN(C[C@H]3C[C@@H]3CNC(=O)c3ccc(cc3)-c3ccccn3)CC2)c1Cl

InChI Key InChIKey=KRMPDMJUDCQCAJ-UHFFFAOYSA-N

Data  5 KI  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50219112   

TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219112(N-(2-(4-(2,3-dichlorophenyl)piperazin-1-ylmethyl)-...)
Affinity DataKi:  1nMAssay Description:Displacement of [125I]IABN from human dopamine D3 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(3) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219112(N-(2-(4-(2,3-dichlorophenyl)piperazin-1-ylmethyl)-...)
Affinity DataIC50: 14.3nMAssay Description:Antagonist activity at human dopamine D3 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219112(N-(2-(4-(2,3-dichlorophenyl)piperazin-1-ylmethyl)-...)
Affinity DataKi:  47.1nMAssay Description:Binding affinity to human 5HT2A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219112(N-(2-(4-(2,3-dichlorophenyl)piperazin-1-ylmethyl)-...)
Affinity DataKi:  53.7nMAssay Description:Displacement of [125I]IABN from human dopamine D2 receptor expressed in HEK293 cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 1A(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219112(N-(2-(4-(2,3-dichlorophenyl)piperazin-1-ylmethyl)-...)
Affinity DataKi:  59nMAssay Description:Binding affinity to human 5HT1A receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
Target5-hydroxytryptamine receptor 2C(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219112(N-(2-(4-(2,3-dichlorophenyl)piperazin-1-ylmethyl)-...)
Affinity DataKi:  79.3nMAssay Description:Binding affinity to human 5HT2C receptorMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219112(N-(2-(4-(2,3-dichlorophenyl)piperazin-1-ylmethyl)-...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at human dopamine D2 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetD(2) dopamine receptor(Human)
National Institute On Drug Abuse-Intramural Research Program

Curated by ChEMBL
LigandPNGBDBM50219112(N-(2-(4-(2,3-dichlorophenyl)piperazin-1-ylmethyl)-...)
Affinity DataIC50: 672nMAssay Description:Antagonist activity at human dopamine D2 receptor expressed in HEK293 cells by mitogenesis assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed