BDBM50220281 1-((2R,6R)-6-ethyl-1-(4-fluorophenylsulfonyl)piperidin-2-yl)cyclopropyl 4-(1-hydroxy-2-methylpropan-2-yl)piperazine-1-carboxylate::CHEMBL236185

SMILES CC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(F)cc1)C1(CC1)OC(=O)N1CCN(CC1)C(C)(C)CO

InChI Key InChIKey=ZHHZSKBELFZJRW-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50220281   

TargetAmyloid-beta precursor protein(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220281(1-((2R,6R)-6-ethyl-1-(4-fluorophenylsulfonyl)piper...)
Affinity DataIC50: 10nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetAmyloid-beta precursor protein(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220281(1-((2R,6R)-6-ethyl-1-(4-fluorophenylsulfonyl)piper...)
Affinity DataIC50: 25nMAssay Description:Inhibition of gamma-secretase assessed as reduction of cell A-beta-40 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed