BDBM50220284 1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiperidin-2-yl)cyclopropyl 4-(piperidin-1-yl)piperidine-1-carboxylate::CHEMBL239859

SMILES CC[C@@H]1CCC[C@@H](N1S(=O)(=O)c1ccc(Cl)cc1)C1(CC1)OC(=O)N1CCC(CC1)N1CCCCC1

InChI Key InChIKey=OWRHDDWGVSCVLM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50220284   

TargetAmyloid-beta precursor protein(Human)
Schering-Plough Research Institute

Curated by ChEMBL
LigandPNGBDBM50220284(1-((2R,6R)-1-(4-chlorophenylsulfonyl)-6-ethylpiper...)
Affinity DataIC50: 3.5nMAssay Description:Inhibition of gamma-secretase assessed as reduction of membrane A-beta-40 levelMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed