BDBM50221986 CHEMBL392469::H-Tyr-Pro-Phe-Phe-NH-CH2-CH2-NH Tic Dmt-H

SMILES Cc1cc(O)cc(C)c1C[C@H](N)C(=O)N1Cc2ccccc2CC1C(=O)NCCNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1

InChI Key InChIKey=CJBITXMCHBQEBZ-UHFFFAOYSA-N

Data  2 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50221986   

TargetMu-type opioid receptor(Rat)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50221986(H-Tyr-Pro-Phe-Phe-NH-CH2-CH2-NH Tic Dmt-H | CHEMBL...)
Affinity DataKi:  1.03nMAssay Description:Displacement of [3H]DAMGO from mu-opioid receptor in Sprague-Dawley rat brain P2 synaptosome membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetDelta-type opioid receptor(Rat)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50221986(H-Tyr-Pro-Phe-Phe-NH-CH2-CH2-NH Tic Dmt-H | CHEMBL...)
Affinity DataKi:  1.45nMAssay Description:Displacement of [3H]deltorphin 2 from delta-opioid receptor in Sprague-Dawley rat brain P2 synaptosome membraneMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetMu-type opioid receptor(Guinea pig)
University of Ferrara

Curated by ChEMBL
LigandPNGBDBM50221986(H-Tyr-Pro-Phe-Phe-NH-CH2-CH2-NH Tic Dmt-H | CHEMBL...)
Affinity DataIC50: 25.1nMAssay Description:Agonist activity at mu-opioid receptor in Hartley guinea pig ileum assessed as inhibition of electrically-stimulated muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed