BDBM50224118 CHEMBL237592::ethyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-(fluoro)phenyl]-1H-pyrrol-3-acetate

SMILES CCOC(=O)Cc1cc(-c2ccc(cc2)S(C)(=O)=O)n(c1C)-c1cccc(F)c1

InChI Key InChIKey=UVNMAAHEMZZIAX-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50224118   

TargetProstaglandin G/H synthase 1(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50224118(ethyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-(...)
Affinity DataIC50: 2.04E+4nMAssay Description:Inhibition of COX1 in human whole blood assessed as TXB2 productionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 1(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50224118(ethyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-(...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of COX1 in mouse J774 cells assessed as arachidonic acid-induced PGE2 levels by radio immunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Human)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50224118(ethyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-(...)
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of COX2 in LPS-induced monocyte assessed as PGE2 production in human whole bloodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed
TargetProstaglandin G/H synthase 2(Mouse)
Sapienza University of Rome

Curated by ChEMBL
LigandPNGBDBM50224118(ethyl-2-methyl-5-[4-(methylsulfonyl)phenyl]-1-[3-(...)
Affinity DataIC50: 10nMAssay Description:Inhibition of COX2 in LPS-stimulated J774 cells assessed as inhibition of PGE2 levels by radioimmunoassayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/10/2009
Entry Details Article
PubMed