BDBM50224351 CHEMBL235717::N-(8-chloro-1-oxo-2-p-tolyl-1H-3,3a,5,9b-tetraaza-cyclopenta[a]naphthalen-4-yl)-4-methoxy-benzamide

SMILES COc1ccc(cc1)C(=O)Nc1nc2ccc(Cl)cc2n2n1nc(-c1ccc(C)cc1)c2=O

InChI Key InChIKey=AFELYHYFSKPYJC-UHFFFAOYSA-N

Data  3 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50224351   

TargetAdenosine receptor A3(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50224351(N-(8-chloro-1-oxo-2-p-tolyl-1H-3,3a,5,9b-tetraaza-...)
Affinity DataIC50: 11.6nMAssay Description:Antagonist activity at human adenosine A3 receptor expressed in CHO cells assessed as inhibition of forskolin-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2b(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50224351(N-(8-chloro-1-oxo-2-p-tolyl-1H-3,3a,5,9b-tetraaza-...)
Affinity DataIC50: 1.00E+3nMAssay Description:Antagonist activity at human adenosine A2B receptor expressed in CHO cells assessed as inhibition of NECA-stimulated cAMP accumulationMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetAdenosine receptor A3(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50224351(N-(8-chloro-1-oxo-2-p-tolyl-1H-3,3a,5,9b-tetraaza-...)
Affinity DataKi:  12.3nMAssay Description:Displacement of [3H]AB-MECA from human adenosine A3 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetAdenosine receptor A2a(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50224351(N-(8-chloro-1-oxo-2-p-tolyl-1H-3,3a,5,9b-tetraaza-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]NECA from human adenosine A2A receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetAdenosine receptor A1(Human)
University of Pisa

Curated by ChEMBL
LigandPNGBDBM50224351(N-(8-chloro-1-oxo-2-p-tolyl-1H-3,3a,5,9b-tetraaza-...)
Affinity DataKi: >1.00E+4nMAssay Description:Displacement of [3H]DPCPX from human adenosine A1 receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed