BDBM50224715 CHEMBL396443::tert-butyl 4-(2-(5-chloro-2-(1-(2-(3-oxo-2,3-dihydrobenzo[b][1,4]oxazin-4-yl)ethyl)piperidin-4-yl)benzamido)ethyl)piperazine-1-carboxylate

SMILES CC(C)(C)OC(=O)N1CCN(CCNC(=O)c2cc(Cl)ccc2C2CCN(CCN3C(=O)COc4ccccc34)CC2)CC1

InChI Key InChIKey=XRDCOVSGDBZMPB-UHFFFAOYSA-N

Data  1 KI  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50224715   

TargetUrotensin-2 receptor(Rat)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224715(tert-butyl 4-(2-(5-chloro-2-(1-(2-(3-oxo-2,3-dihyd...)
Affinity DataIC50: 10nMAssay Description:Antagonist activity at rat UT receptor transfected in CHOK1 cells assessed as calcium mobilization by FLIPR methodMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetUrotensin-2 receptor(Human)
Johnson & Johnson Pharmaceutical Research & Development

Curated by ChEMBL
LigandPNGBDBM50224715(tert-butyl 4-(2-(5-chloro-2-(1-(2-(3-oxo-2,3-dihyd...)
Affinity DataKi:  65nMAssay Description:Displacement of [125I]U2 from human UT receptor in RMS13 cells after 2.5 hrsMore data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed