BDBM50228551 4-(4-fluoro-benzoyl)-1-[4-(3-piperidin-1-yl-propoxy)-phenyl]-piperazin-2-one formic acid::CHEMBL239975::CHEMBL240185

SMILES Fc1ccc(cc1)C(=O)N1CCN(C(=O)C1)c1ccc(OCCCN2CCCCC2)cc1

InChI Key InChIKey=GXILWBIQFGWJQN-UHFFFAOYSA-N

Data  6 IC50  2 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50228551   

TargetCytochrome P450 1A2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(CHEMBL240185 | CHEMBL239975 | 4-(4-fluoro-benzoyl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP1A2More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetCytochrome P450 2D6(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(CHEMBL240185 | CHEMBL239975 | 4-(4-fluoro-benzoyl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2D6More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(CHEMBL240185 | CHEMBL239975 | 4-(4-fluoro-benzoyl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP3A4 using 7-benzloxyquinolone substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C9(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(CHEMBL240185 | CHEMBL239975 | 4-(4-fluoro-benzoyl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2C9More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetCytochrome P450 3A4(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(CHEMBL240185 | CHEMBL239975 | 4-(4-fluoro-benzoyl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP3A4 using diethoxyfluorescein substrateMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetCytochrome P450 2C19(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(CHEMBL240185 | CHEMBL239975 | 4-(4-fluoro-benzoyl)...)
Affinity DataIC50: 1.00E+5nMAssay Description:Inhibition of human CYP2C19More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetHistamine H1 receptor(Guinea pig)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(CHEMBL240185 | CHEMBL239975 | 4-(4-fluoro-benzoyl)...)
Affinity DataKd: >1.00E+3nMAssay Description:Antagonist activity at histamine H1 receptor in guinea pig ileum assessed as inhibition of histamine-induced longitudinal smooth muscle contractionMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed
TargetHistamine H3 receptor(Guinea pig)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50228551(CHEMBL240185 | CHEMBL239975 | 4-(4-fluoro-benzoyl)...)
Affinity DataKd:  3.98nMAssay Description:Antagonist activity at histamine H3 receptor in guinea pig ileum assessed as inhibition of (R)-methyl histamine induced longitudinal smooth muscle co...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2012
Entry Details Article
PubMed