BDBM50228914 5-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)acetyl)-1-(4-methoxyphenyl)-1H-pyrazole-3-carboxamide::CHEMBL403042

SMILES COc1ccc(cc1)-n1nc(cc1C(=O)Cc1ccc(cc1F)-n1ccccc1=O)C(N)=O

InChI Key InChIKey=MRPLIGSOQUCMBC-UHFFFAOYSA-N

Data  8 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50228914   

TargetCoagulation factor X(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228914(5-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)ace...)
Affinity DataKi:  0.110nMAssay Description:Inhibition of human factor 10aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetPlasma kallikrein(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228914(5-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)ace...)
Affinity DataKi:  8.90E+3nMAssay Description:Inhibition of human plasma kallikreinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetProthrombin(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228914(5-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)ace...)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human thrombinMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCoagulation factor IX(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228914(5-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)ace...)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human factor 9aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetCoagulation factor XI(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228914(5-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)ace...)
Affinity DataKi: >1.50E+4nMAssay Description:Inhibition of human factor 11aMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetPlasminogen(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228914(5-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)ace...)
Affinity DataKi: >2.80E+4nMAssay Description:Inhibition of human plasminMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetVitamin K-dependent protein C(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228914(5-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)ace...)
Affinity DataKi: >3.80E+4nMAssay Description:Inhibition of human activated protein CMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetTissue-type plasminogen activator(Human)
Bristol-Myers Squibb Research and Development

Curated by ChEMBL
LigandPNGBDBM50228914(5-(2-(2-fluoro-4-(2-oxopyridin-1(2H)-yl)phenyl)ace...)
Affinity DataKi: >4.30E+4nMAssay Description:Inhibition of human tPAMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed