BDBM50229191 CHEMBL252409::US9096559, 15::[4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbamic acid benzyl ester

SMILES Nc1ccc(cc1NC(=O)c1ccc(CNC(=O)OCc2ccccc2)cc1)-c1ccccc1

InChI Key InChIKey=XNNFDOVUKNVDRN-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 50229191   

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229191([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 58nMAssay Description:Novel compounds were tested for their ability to inhibit histone deacetylase, subtype 1 (HDAC1) using an in vitro deacetylation assay. The enzyme sou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2016
Entry Details
Go to US Patent

TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229191([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 17nMAssay Description:Inhibition of HDAC1More data for this Ligand-Target Pair
In Depth
Date in BDB:
11/11/2009
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229191([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 1.45E+4nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHistone deacetylase 1(Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50229191([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 1.88E+3nMAssay Description:Inhibition of human recombinant HDAC1 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectroflu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50229191([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 3.80E+4nMAssay Description:Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 5 mins measured after 35 mins by spectrofl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50229191([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 1.40E+4nMAssay Description:Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 3 hrs measured after 35 mins by spectroflu...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed
TargetHistone deacetylase 2(Human)
University of Illinois At Chicago

Curated by ChEMBL
LigandPNGBDBM50229191([4-(4-amino-biphenyl-3-ylcarbamoyl)-benzyl]-carbam...)
Affinity DataIC50: 740nMAssay Description:Inhibition of human recombinant HDAC2 using Boc-L-Lys (Ac)-AMC as substrate preincubated with compound for 24 hrs measured after 35 mins by spectrofl...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/8/2013
Entry Details Article
PubMed