BDBM50232433 CHEMBL4068514::US10214537, Example 619

SMILES CC(=O)N1CCN(C(=O)C1(C)C)c1cccc(c1)-c1cc(-c2ccnn2C2CCOCC2)c2c(N)ncnn12

InChI Key InChIKey=RIQACLQMPHPJFB-UHFFFAOYSA-N

Data  8 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50232433   

LigandPNGBDBM50232433(CHEMBL4068514 | US10214537, Example 619)
Affinity DataIC50: 0.300nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate incubated for 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2019
Entry Details Article
PubMed
LigandPNGBDBM50232433(CHEMBL4068514 | US10214537, Example 619)
Affinity DataIC50: 0.5nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

LigandPNGBDBM50232433(CHEMBL4068514 | US10214537, Example 619)
Affinity DataIC50: 3nMAssay Description:The ADP-Glo format PI3K assays were performed in Proxiplate 384-well plates (Perkin Elmer #6008280). The final assay volume was 2 μl prepared fr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/20/2019
Entry Details
Go to US Patent

LigandPNGBDBM50232433(CHEMBL4068514 | US10214537, Example 619)
Affinity DataIC50: 21nMAssay Description:Inhibition of PI3Kgamma (unknown origin) using PIP2:PS as substrate after 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50232433(CHEMBL4068514 | US10214537, Example 619)
Affinity DataIC50: 59nMAssay Description:Inhibition of PI3Kalpha (unknown origin) using PIP2:PS as substrate after 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50232433(CHEMBL4068514 | US10214537, Example 619)
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of PI3Kbeta (unknown origin) using PIP2:PS as substrate after 30 mins by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50232433(CHEMBL4068514 | US10214537, Example 619)
Affinity DataIC50: 0.5nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using PIP2:PS as substrate after 3 hrs by ADP-Glo assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed
LigandPNGBDBM50232433(CHEMBL4068514 | US10214537, Example 619)
Affinity DataIC50: 7nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-IgD-mediated B-cell activation by measuring decrease in CD19+ cells expres...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/25/2019
Entry Details Article
PubMed