BDBM50232685 CHEMBL4096085::US11358936, Compound 4-4

SMILES NCc1ccnc(c1)C(F)(F)F

InChI Key InChIKey=LETQLOMLPJORPB-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 50232685   

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity is evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells stably expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/19/2022
Entry Details
US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50: 999nMAssay Description:Inhibition of full length recombinant human LOXL2 expressed in CHO cells assessed as reduction in H2O2 production using DAP as substrate preincubated...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2019
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50: 1.00E+3nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of human LOXL2 expressed in CHO cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs fo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50: 7.90E+3nMAssay Description:Inhibition of recombinant human LOXL2 expressed in human whole blood assessed as reduction of H2O2 production from oxidative deamination of DAP prein...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed
TargetProtein-lysine 6-oxidase(Human)
Pharmakea Therapeutics

Curated by ChEMBL
LigandPNGBDBM50232685(CHEMBL4096085 | US11358936, Compound 4-4)
Affinity DataIC50: 5.40E+4nMAssay Description:Inhibition of human LOX expressed in HEK cells assessed as reduction of H2O2 production from oxidative deamination of DAP preincubated for 2 hrs foll...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/20/2020
Entry Details Article
PubMed