BDBM50232861 CHEMBL2131647::US11225469, Compound 24

SMILES Cc1cc(C)nc(NC(=S)N2CCN(CC2)c2cccc(c2)C(F)(F)F)c1

InChI Key InChIKey=UHILQSVKIPUHLB-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50232861   

TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50232861(CHEMBL2131647 | US11225469, Compound 24)
Affinity DataIC50: 6.30E+3nMAssay Description:Inhibition of N-terminal His6-tagged human liver PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3-phosphoglycerate as substrate after 2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2020
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50232861(CHEMBL2131647 | US11225469, Compound 24)
Affinity DataIC50: 6.50E+3nMAssay Description:Inhibition of human liver N-terminal His6-tagged PHGDH expressed in Escherichia coli Rosetta (DE3)pLysS using 3 -phosphoglycerate as substarte measur...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2019
Entry Details Article
PubMed
TargetD-3-phosphoglycerate dehydrogenase(Human)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50232861(CHEMBL2131647 | US11225469, Compound 24)
Affinity DataIC50: 7.50E+3nMAssay Description:PHGDH assay buffer contained 50 mM TEA pH 8.0, 10 mM MgCl2, 0.05% BSA, and 0.01% Tween-20. PHGDH enzyme buffer consisted of assay buffer with 20 nM P...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/22/2022
Entry Details
US Patent