BDBM50233667 CHEMBL4088969

SMILES COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1)-c1ccc2ncn([C@H]3CCN(CC4CC4)C3)c(=O)c2c1

InChI Key InChIKey=CIEPFNWWFNULHV-UHFFFAOYSA-N

Data  5 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50233667   

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Xi'An Jiaotong University

Curated by ChEMBL

LigandBDBM50233667(CHEMBL4088969)Copy SMILESCopy InChI

Affinity DataIC50: 6.70nMAssay Description:Inhibition of P110alpha/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
6/6/2019
Entry Details Article
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TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Xi'An Jiaotong University

Curated by ChEMBL

LigandBDBM50233667(CHEMBL4088969)Copy SMILESCopy InChI

Affinity DataIC50: 21nMAssay Description:Inhibition of P110delta/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
6/6/2019
Entry Details Article
Copy Entry DOIPubMed
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TargetSerine/threonine-protein kinase mTOR(Human)
Xi'An Jiaotong University

Curated by ChEMBL

LigandBDBM50233667(CHEMBL4088969)Copy SMILESCopy InChI

Affinity DataIC50: 114nMAssay Description:Inhibition of mTOR (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
6/6/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Xi'An Jiaotong University

Curated by ChEMBL

LigandBDBM50233667(CHEMBL4088969)Copy SMILESCopy InChI

Affinity DataIC50: 24nMAssay Description:Inhibition of P110beta/p85alpha (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

Target InfoPDB
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
6/6/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL

TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform/Phosphoinositide 3-kinase regulatory subunit 5(Human)
Xi'An Jiaotong University

Curated by ChEMBL

LigandBDBM50233667(CHEMBL4088969)Copy SMILESCopy InChI

Affinity DataIC50: 181nMAssay Description:Inhibition of P110gamma/PIK3R5 (unknown origin) using L-alpha-phosphatidylinositol as substrate after 40 mins by ATP depletion assayMore data for this Ligand-Target Pair

Target InfoPDBKEGG
UniProtKB/SwissProt
GoogleScholar

Ligand InfoCHEMBLPC cidPC sidSimilars

In Depth
Date in BDB:
6/6/2019
Entry Details Article
Copy Entry DOIPubMed
Copy Rxn URL