BDBM50233773 (R)-N-(1-oxo-1-((3-(1-phenylcyclopropyl)-3H-imidazo[4,5-b]pyridin-2-yl)methylamino)-3-(2,3,6-trifluorophenyl)propan-2-yl)-1-(trifluoromethyl)cyclopropanecarboxamide::CHEMBL403809

SMILES Fc1ccc(F)c(C[C@@H](NC(=O)C2(CC2)C(F)(F)F)C(=O)NCc2nc3cccnc3n2C2(CC2)c2ccccc2)c1F

InChI Key InChIKey=AMSKTYLOKZVQRX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50233773   

TargetCytochrome P450 3A4(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233773((R)-N-(1-oxo-1-((3-(1-phenylcyclopropyl)-3H-imidaz...)
Affinity DataIC50: 980nMAssay Description:Inhibition of CYP3A4More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 9 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233773((R)-N-(1-oxo-1-((3-(1-phenylcyclopropyl)-3H-imidaz...)
Affinity DataIC50: 182nMAssay Description:Blockade of human Nav1.7 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed
TargetSodium channel protein type 10 subunit alpha(Human)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50233773((R)-N-(1-oxo-1-((3-(1-phenylcyclopropyl)-3H-imidaz...)
Affinity DataIC50: 446nMAssay Description:Blockade of human Nav1.8 channel expressed in HEK293 cells by FRET assayMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/14/2012
Entry Details Article
PubMed